Complementary & Alternative Medicine

Biography

Biography: Ali M. Mutlag

Abstract

Fertility in mammalian females is dependent on the growth of follicles, structural units consisting of an oocyte, granulosa cells, and theca cells with an extracellular matrix separating the cell layers. The ovaries play the key roles in reproduction and any impairment in their functions can result in either sterility or infertility. Traditional Chinese medicine (TCM) plays a very important role in health keeping. Alternative holistic therapies, such as Traditional Chinese Medicine, offer less invasive and less costly physical and emotional treatment compared with standard Western medical treatment. However, awareness of TCM therapy for infertility is generally low and often not suggested by Western Medical practitioners. Western medical treatment could depress the blood pressure rapidly and surely through reducing blood volume and dilating blood vessels, while traditional medicine (TM) shows its superiorities in alleviating clinical symptoms, improving patients' quality of life, lessening or reversing the damage on terminal organs and preventing the occurrence of a serious complication. Herbal leisure, also named Chinese Motherwort or Siberian Motherwort, belongs to the Labiatae family in the plant kingdom. Native to China, central Europe, Scandinavia, and Russia, it is now naturalized in Japan, Java, Malaysia, and North America. Radix Salvia miltiorrhizae (RSM), the root of Salvia miltiorrhiza Bunge, is one of the most widely used traditional herbal medicines for the treatment of a variety of conditions. It is commonly used either alone or in combination with other herbs in traditional Chinese medicine for the prevention and treatment of numerous ailments, including coronary artery disease, hypertension, hyperlipidemia, stroke, renal diseases, and diabetes, peripheral and pulmonary vascular disease. Cadmium chloride (CdCl₂) used in this study to induced infertility of female Wister rats IP injection , many parameters were conducted in this study to evaluated the treatment using Chinese herbs mentioned above these parameters include (FSH, LH, E2, INH-B, INH-A) and quantitative gene expression of (Matrix Metalloproteinase (MMP-1, 2) and Sterile motif alpha domain containing 3 (Smad3). Conclusion the study approved using a combination of Herba leonuri and Radix salviae miltiorrhizae provided optimum treatment of female infertility through repairing the ovarian function and adjustment the levels of hormones to the normal values, maintain the endocrine mechanism related to the reproduction and the ovarian functions by increase the quality and numbers of developing follicles due to augmentation of the molecules referring to increasing the numbers and maturation of the follicles (Inhibins, hormones, MMP1, 2 and the Newly aspect approves through positive effects on expression of Smad3 gene in the ovarian tissue.